Abraxane in Combination With Carboplatin, Erbitux and IMRT for Locally Advanced Squamous Cancer of the Head and Neck

Inclusion Criteria: * Histologically or cytologically proven squamous cell carcinoma of th head and neck or its variants. Primary tumor sites eligible include nasopharynx, oral cavity, oropharynx, hypopharynx, larynx, or unknown primary SSCHN. Although they have squamous histology, tumors of the skin, nasal cavity and paranasal sinuses are excluded because their responsiveness to chemotherapy and radiotherapy may differ. * Stage III or IV disease, without evidence of distant metastasis, according to the American Joint Committee on Cancer. * Measurable disease, according to RECIST. * Treatment-naive SSCHN, i.e. no prior chemotherapy, radiotherapy or attempted complete resection. * \< CTCAE v3.0 Grade 2 neuropathy * 18 years of age or older * ECOG Performance Status of 0 or 1 * No active alcohol addiction or other condition that, in the opinion of the study investigators, would interfere with the subject's ability to comply with the treatment plan. * Lab values as outlined in the protocol * Negative pregnancy test within 7 days of study entry Exclusion Criteria: * Pregnant or breast-feeding women, or women and men of childbearing potential not willing to use adequate contraception while receiving treatment and for at least 6 months thereafter. * Symptomatic peripheral neuropathy Grade 2 or greater by CTCAE v3.0 * History of other malignancy within the previous 5 years, except for non-melanoma skin cancer, carcinoma in situ of the cervix, bladder or head and neck. * Prior the…