Efficacy and Safety of Oral Dehydroepiandrosterone as a Concomitant Therapy to Oral Contraceptives in Women Complaining of Reduced Libido

Inclusion Criteria: * Treatment with a oral contraceptive (OC) for at least 3 months and willing to continue the OC * Loss of libido * Sexual relationship with a sexually competent partner Exclusion Criteria: * Female sexual dysfunction other than HSDD, arousal and orgasmic disorder, such as sexual aversion/phobic disorder, sexual pain disorder/dyspareunia * Hyperandrogenemic conditions, such as congenital adrenal hyperplasia (CAH), polycystic ovary syndrome (PCOS), Cushing's syndrome or signs of hyperandrogenism like severe hirsutism or severe acne * Presence or a history of venous or arterial thrombotic/thromboembolic events (e.g., deep venous thrombosis, pulmonary embolism, myocardial infarction) or of a cerebrovascular accident. * Presence or history of prodromi of a thrombosis (e.g., transient ischaemic attack, angina pectoris). * History of migraine with focal neurological symptoms. * Diabetes mellitus with vascular involvement. * Presence of a severe or multiple risk factor(s) for venous or arterial thrombosis * Pancreatitis or a history thereof if associated with severe hypertriglyceridemia * Presence or history of severe hepatic disease as long as liver function values have not returned to normal. * Presence or history of liver tumors (benign or malignant). * Known or suspected sex-steroid influenced malignancies (e.g., of the genital organs or the breasts) * Undiagnosed vaginal bleeding. * Known or suspected pregnancy. * Hypersensitivity to the active substances …