Safety and Effect of Oral Doses of 5mg or 10mg of SLx-2101 for 14 Days in Patients With Hypertension

Inclusion Criteria: * Male or female subjects between 18 and 70 years old, inclusive * Moderate to severe hypertension * Body weight within a body mass index of 18-32kg/m2 Exclusion Criteria: * The subject is receiving more than three antihypertensive agents * A history of drug abuse * Exposure to a new chemical entity within 3 months prior to the first day of dosing