Pre-Exposure Prophylaxis to Prevent HIV-1 Acquisition Within HIV-1 Discordant Couples

Inclusion Criteria for HIV-1 uninfected partner: * Partner within an HIV-1 discordant heterosexual relationship * One partner meets study eligibility for HIV-1 uninfected study participant and the other partner meets study eligibility criteria for HIV-1 infected participant * Plan to remain in the relationship for the duration of the study period * Adequate renal, hepatic \& hematologic function * Negative Hepatitis B surface antigen test * Willing and able to provide written informed consent \& locator information Exclusion Criteria for HIV-1 uninfected partner: * Current pregnancy, or planning to become pregnant during the study period * Currently breastfeeding * Concurrent enrollment in another HIV-1 vaccine or prevention trial * Receiving ongoing antiretroviral therapy * Repeated positive urine dipstick tests for glycosuria or proteinuria * Active and serious infections * History of pathological bone fractures not related to trauma Inclusion Criteria for HIV-1 infected partner: * Partner within an HIV-1 discordant heterosexual relationship * One partner meets study eligibility for HIV-1 uninfected study participant and the other partner meets study eligibility criteria for HIV-1 infected participant * HIV-1 infected based on positive EIA * No history of any clinical AIDS-defining diagnoses * Plan to remain in the relationship for the duration of the study period * Willing and able to provide written informed consent \& locator information Exclusion Criteria for HIV-…