Therapeutic Utility of Xolair in Patients Undergoing Aspirin Desensitization

Inclusion Criteria: * Age \> 18 years. * Fulfill diagnostic criteria for AERD (described below), and be a candidate for aspirin desensitization chronic asthma - frequently moderate-severe or severe patients will have history compatible with variable airflow obstruction. chronic rhinosinusitis - usually requiring previous sinus surgery procedure(s). sinusitis will have been confirmed by imaging studies presently and/or in the past. history of adverse reaction to aspirin and/or aspirin-like drugs (e.g., ibuprofen, naproxen, etc.) compatible with AERD. • Candidate for Xolair \[Omalizumab\] Moderate-severe persistent asthma IgE = 30-700 IU/ml IgE mediated (allergic) potential to inhalant allergen(s) by cutaneous or in vitro testing. Exclusion Criteria: * Women of childbearing potential not using appropriate contraception method(s) * Women currently breastfeeding * Women who desire to become pregnant during the time of participation in this study * Men who desire to get someone pregnant during participation in this study * Known sensitivity to Xolair \[Omalizumab\]. * IgE level \< 30 IU/ml, or \> 700 IU/ml. * No evidence of atopy by immediate hypersensitivity skin testing * Use of any other investigational agent in the last 30 days * Age \< 18 years. * Current tobacco habituation. * Presence of emphysema * Ethanolism or drug abuse within last 12 months. * Presence of significant medical condition including malignancy, neurologic, kidney, gastrointestinal, liver or cardiovascu…