Danish ICD Study in Patients With Dilated Cardiomyopathy

Inclusion Criteria: * ≥ 18 years of age at the time of screening. * Documented non-ischemic HF with an LVEF ≤ 35%. * NYHA class II-III. If patients are planned for an implantation with a biventricular pacemaker NYHA class IV patients will be accepted for the trial. * Before any study-specific procedure, including assessments for screening, the appropriate written informed consent must be obtained (see section 12.1). * NT-proBNP above 200 pg/ml (see appendix D). Exclusion Criteria: To be eligible for this study, subjects must not meet any of the following criteria: * Uncorrected congenital heart disease or valve obstruction, obstructive cardiomyopathy, active myocarditis, constrictive pericarditis, untreated hypothyroidism or hyperthyroidism, adrenal insufficiency, active vasculitis due to collagen vascular disease. * On the urgent waiting list for a heart transplant (UNOS category 1A or 1B, or equivalent). Patients on the non-urgent waiting list for a heart transplant (UNOS category 2 or 7, or equivalent) are eligible for inclusion in the study. * Recipient of any major organ transplant (eg, lung, liver, heart or kidney). * Receiving or has received cytotoxic or cytostatic chemotherapy and/or radiation therapy for treatment of a malignancy within 6 month before randomisation or clinical evidence of current malignancy, with the following exceptions: basal or squamous cell carcinoma of the skin, cervical intraepithelial neoplasia, prostate cancer (if stable localized diseas…