Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion (NCT00538616) | Clinical Trial Compass
CompletedPhase 1/2
Precedex Versus Propofol-Awakening for Reducing Brain Injury Expansion
United States8 participantsStarted 2008-01
Plain-language summary
The purpose of this study is to evaluate brain injury when two different drugs (propofol and precedex) are used to sedate patients who need a neurologic exam.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* primary diagnosis of Traumatic Brain Injury (TBI), Subarachnoid Hemorrhage (SAH),Intracranial Hemorrhage (ICH), stroke
* Must require (be on) mechanical ventilation
* must require (have in place) intracranial pressure (ICP) monitoring
* must require (be receiving) continuous IV sedation
Exclusion Criteria:
* Bleeding diathesis
* Glasgow Coma Scale (GCS) \< 5 with fixed pupils
* Pregnant
* elevated ICP that requires deep sedation
* pulmonary instability
* Hx of Ethanol(ETOH) abuse that requires current benzodiazepine treatment for delirium - allergy to propofol or precedex
* status epilepticus
* current neuromuscular blockade