The SPECTRA Study

Inclusion Criteria: * Diagnosed with RA as determined by American College of Rheumatology (ACR) criteria (Appendix C) * Disease duration of no less than 12 weeks of diagnosis confirmed by physician and source documentation * Disease duration \< 10 years * Active RA at baseline as defined by a minimum of 6 or more swollen joints and 9 or more tender/painful joints (based on a 66/68-joint count excluding distal interphalangeal joints) at screening and baseline, And * C-reactive protein (CRP) \> 2 mg/dL at screening. * Have active clinical synovitis in the knee as determined by the investigator based on clinical evaluation * 18 years of age or older * Men or non-pregnant (negative serum HCG at screening unless surgically sterile or postmenopausal), non-breast-feeding women may be enrolled. Females of childbearing potential and males must use adequate contraceptive precautions as determined by the principal investigator. * Subjects that have taken any DMARD for less than 3 months must not have taken DMARDs within 4 weeks prior to screening. Subjects that have taken any DMARD for longer than 3 months must not have taken DMARDs within 6 months of screening. * Subject's doses of NSAIDs and oral corticosteroids (10 mg/day of prednisone or equivalent) must have been kept stable for 4 weeks before screening * Subjects must not have had intrarticular injections in the joint that will be arthroscoped for at least 3 months prior to screening. Before any study specific procedure or scr…