Efficacy and Tolerance of Naked DNA Vaccine in Patients With Chronic B Hepatitis

Inclusion Criteria: * chronic hepatitis B with or without AgHBe * no cirrhosis and no hepatocellular carcinoma * treatment with NRTI unchanged for at least 3 months * undetectable HBV viral load for 12 months * HBV viral load \< 12 IU/ml at screening * sGPT \< 5N * tetanus immunization or booster dose for less than 8 years * accurate birth control or menopausal women or sterility * sickness insurance * signed informed consent Exclusion Criteria: * HLA-DR 15/16 * coinfections with HDV, HCV and/or HIV * treatment with immunomodulators * immunosuppressors * long-term corticotherapy (over 4 weeks) * active intravenous drug-users * prolonged and excessive consumption of alcohol (men \> 40g/day ; women \> 30g/day ; for more than 5 years) * medical history of autoimmune disease or presence of autoantibodies * previous immunization by HBV vaccine of less than 5 years * previous immunization by DNA vaccine against HBV * personal or family medical history of demyelinising diseases * uncontrolled hypophosphatemia * renal failure, renal transplantation, haemodialysis * pregnancy, breast-feeding