Donor Lymphocyte Infusion in Treating Patients With Recurrent or Persistent Hematologic Cancer Af… (NCT00534118) | Clinical Trial Compass
CompletedNot Applicable
Donor Lymphocyte Infusion in Treating Patients With Recurrent or Persistent Hematologic Cancer After Donor Stem Cell Transplant
United States39 participantsStarted 2003-10-01
Plain-language summary
RATIONALE: Giving an infusion of donor lymphocytes may be able to kill cancer cells in patients with hematologic cancer that has come back after a donor stem cell transplant.
PURPOSE: This clinical trial is studying how well donor lymphocyte infusion works in treating patients with recurrent or persistent hematologic cancer after donor stem cell transplant.
Who can participate
Age range76 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Has undergone allogeneic stem cell transplantation (ASCT) for hematologic malignancy at least 30 days ago
* No failure to engraft following transplant
* No active acute or chronic graft-versus-host disease (GVHD)
* Minimal GVHD allowed
* Persistent or relapsed disease after ASCT, including 1 of the following:
* Chronic myelogenous leukemia (CML), meeting any of the following criteria:
* Molecular relapse (may be treated with imatinib mesylate after transplant), as defined by any of the following:
* ASCT was non-T-cell depleted, a negative bcr/abl was documented by PCR post-transplant, and bcr/abl is now detectable by 2 consecutive PCR determinations \> 30 days apart
* ASCT was non-T-cell depleted and bcr/abl is detectable by PCR at any time after day 180 post-transplant
* Cytogenetic relapse after 3-6 months of imatinib mesylate
* Relapsed chronic phase, accelerated phase, or blastic phase CML after 3-6 months of imatinib mesylate
* Must currently be in chronic phase or accelerated phase CML only
* Patients with blastic phase CML must attain a second chronic phase
* Acute myeloid leukemia, acute lymphoblastic leukemia, or myelodysplastic syndromes, meeting any of the following criteria:
* Molecular relapse, as evidenced by \< 5% blasts in the bone marrow and the patient's leukemia-specific molecular abnormality detectable by PCR
* Cytogenetic relapse, as evidenced by \< 5% blasts in the…
What they're measuring
1
Complete Remission Rate
Timeframe: 100 days post DLI
2
Duration of Complete Response in Months (Maximum 12)