IL-11 in Adults With Von Willebrand Disease Undergoing Surgery

Inclusion Criteria: * Males and females 18 years of age and older * Confirmed type 1 VWD, as defined by low VWF:RCoF or low VWF:Ag and qualitatively normal VWF multimers * A past bleeding history * Responsive to DDAVP * Scheduled elective major surgery or major dental surgery at MUH or PUH * Willingness to have blood drawn Exclusion Criteria: * Presence of other bleeding disorders, acquired Von Willebrand disease, primary thrombocytopenia * Use of immunomodulatory or experimental drugs, or diuretics * Pregnant or lactating women or those unwilling to use contraception during study * Previous cardiac disease, congestive failure, arrhythmia (e.g. atrial fibrillation, atrial flutter), hypertension, MI, stroke, or thrombosis * Past allergic reaction to Neumega or DDAVP * Surgery within the past 8 weeks * Inability to comply with study protocol requirements * Concomitant use of antiplatelet drugs, anticoagulants, dextran, aspirin or NSAIDs * Treatment with DDAVP, cryoprecipitate, whole blood, plasma and plasma derivatives containing substantial quantities of FVIII and/or VWF within five days of study * Past allergic reaction to Neumega or DDAVP * Surgery within the past 8 weeks * Inability to comply with study protocol requirements * Concomitant use of antiplatelet drugs, anticoagulants, dextran, aspirin or NSAIDs * Treatment with DDAVP, cryoprecipitate, whole blood, plasma and plasma derivatives containing substantial quantities of FVIII and/or VWF within five days of study