A Study of Safety, Tolerability, and Pk of rhMBL in Pediatric Hematology/Oncology Pts With Fever and Neutropenia

Inclusion Criteria: Patients must meet all of the following criteria to be eligible for enrollment into the study: * Children ages 2 to 17 receiving chemotherapy for hematological/oncological diseases. * Patients must have documented MBL levels \<300 ng/mL in serum as evaluated in the screening protocol. * Fever defined as an oral temperature equivalent of \>100.4°F (38°C). * Neutropenia defined as an absolute neutrophil count ≤1,000/mm3 with the anticipation that the counts will fall below 500/mm3. * Receiving broad spectrum antibiotics for fever and neutropenia. * Patients with age-adjusted normal serum creatinine OR a creatinine clearance \>60 mL/min/1.73m2. * Informed consent of the patient, parent or legally authorized representative obtained prior to entry. * Reliable and willing to make themselves available for the duration of the study and to abide by the study restrictions. Exclusion Criteria: Patients meeting any of the following exclusion criteria will not be eligible for enrollment. * Patients receiving the preparative regimen for a bone marrow or hematopoietic stem cell transplantation. * Concurrent serious illness in the opinion of the principal investigator that could potentially interfere with protocol compliance. * Patient is pregnant, breast feeding or planning a pregnancy during the course of the study. * Sexually active male and female patients not using an acceptable barrier method of contraception or practicing abstinence throughout the study and for …