Evaluation of Carboplatin/Paclitaxel/Bevacizumab in the Treatment of Advanced Stage Endometrial C… (NCT00513786) | Clinical Trial Compass
CompletedPhase 2
Evaluation of Carboplatin/Paclitaxel/Bevacizumab in the Treatment of Advanced Stage Endometrial Carcinoma
United States38 participantsStarted 2007-08-01
Plain-language summary
Purpose of this study is to determine the effectiveness of the drug combination carboplatin, paclitaxel, and bevacizumab(Avastin) in patients with advanced stage endometrial carcinoma.
Who can participate
Age range18 Years
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Advanced Stage Endometrial Cancer (Stage 3 or 4)
* Any Histology including clear cell, and serous papillary carcinomas
* surgery must have had hysterectomy and bilateral salpingo-oophorectomy
* chemotherapy initiated 12 weeks after surgery
* sign informed consent
* Adequate End-organ function
* GOG (Gynecologic Oncology Group)Performance Status 0,1,2
* Patients must be 18 years or older
* Patients may have received radiation for the treatment of endometrial cancer.
* Patients may have measurable or non-measurable disease.
Exclusion Criteria:
* Patient with concomitant malignancy other than non-melanoma skin cancer
* Patients with prior malignancy who have been disease free for 5 years.
* Patients with serious uncontrolled infection, angina or serious peripheral neuropathy.
* Patients whose circumstances will not permit study completion or adequate follow up
* Patients who have received prior cytotoxic chemotherapy for treatment of endometrial cancer including chemotherapy used for radiation sensitization.
What they're measuring
1
Evaluate Patients With Progression Free Survival (PFS)