Rasburicase in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer or Other … (NCT00513474) | Clinical Trial Compass
CompletedPhase 1
Rasburicase in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer or Other Disease Undergoing Donor Stem Cell Transplant
United States46 participantsStarted 2008-01
Plain-language summary
RATIONALE: Rasburicase may be an effective treatment for graft-versus-host disease caused by a donor stem cell transplant.
PURPOSE: This clinical trial is studying how well rasburicase works in preventing graft-versus-host disease in patients with hematologic cancer or other disease undergoing donor stem cell transplant.
Who can participate
Age range18 Years – 65 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Patients with hematologic malignancies for whom conventional myeloablative allogeneic stem cell transplantation is deemed clinically appropriate and who are eligible for conventional myeloablative allogeneic stem cell transplantation on treatment plans/protocols, including any of the following:
* Non-Hodgkin lymphoma or Hodgkin lymphoma (relapsed or refractory disease)
* Chronic lymphocytic leukemia (received more than one previous treatment regimen)
* Acute myelogenous or lymphoblastic leukemia (AML/ALL) (high-risk disease, in first complete remission \[CR1\] or subsequent remission, or primary refractory disease)
* Chronic myelogenous leukemia in tyrosine-kinase resistant chronic phase, accelerated or blast phase, or primary refractory disease
* Myelodysplastic syndromes in International Prognostic Scoring System (IPSS) high-intermediate or high-risk groups
* Other hematologic disorders for which allogeneic stem cell transplantation is appropriate (e.g., myelofibrosis)
* Patients who have relapsed after standard autologous and/or allogeneic bone marrow transplant are eligible
* Must be receiving filgrastim (G-CSF)-mobilized related or unrelated donor allogeneic peripheral blood stem cells
* Patients receiving hematopoietic stem cells of any other sources such as a marrow graft or umbilical cord blood will not be eligible for this study
* Donor must be HLA-genotypically or phenotypically 6 of 6 antigen matched (at the A, B, DR loci…
What they're measuring
1
Percentage of Participants With Grades II to IV Acute Graft-Versus-Host Disease (aGVHD)