Dasatinib in Treating Patients With Previously Treated Malignant Mesothelioma (NCT00509041) | Clinical Trial Compass
CompletedPhase 2
Dasatinib in Treating Patients With Previously Treated Malignant Mesothelioma
United States46 participantsStarted 2007-08
Plain-language summary
RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
PURPOSE: This phase II trial is studying how well dasatinib works in treating patients with previously treated malignant mesothelioma.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically confirmed malignant mesothelioma of any of the following subtypes:
* Epithelial
* Sarcomatoid
* Mixed
* Any site of origin of malignant mesothelioma allowed including, but not limited to, any of the following:
* Pleura
* Peritoneum
* Pericardium
* Tunica vaginalis
* Pathology blocks or slides from a core surgical biopsy must be available
* Not amenable to curative surgery
* Measurable disease, defined as lesions that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques (CT scan , MRI, or x-ray) or as ≥ 10 mm with spiral CT scan
* Patients with pleural rind only disease must have at least one level with one rind measurement ≥ 1.5 cm
* Lesions that are considered nonmeasurable include the following:
* Bone lesions
* Leptomeningeal disease
* Ascites
* Pleural/pericardial effusion
* Lymphangitis cutis/pulmonis
* Abdominal masses that are not confirmed and followed by imaging techniques
* Cystic lesions
* Prior treatment with one and only one systemic chemotherapy regimen, which must have included pemetrexed disodium required
* Treatment may have been with pemetrexed disodium alone or in combination with any other agent
* No symptomatic pleural effusions, unless the patient undergoes a therapeutic thoracentesis
* Patients with pleural effusions who have had a pleurodesis are eligible
* No known brain metastases…