CompletedPhase 2/3

To Study the Effectiveness and Safety of Niacin and a Topical Steroid Eye Drop to Treat Retinal Vein Occlusions

United States63 participantsStarted 2006-10

Plain-language summary

The purpose of this study is to determine whether Niacin, a B vitamin, may act as a vasodilator to encourage earlier formation of collateral blood vessels that may serve to bypass the obstructed vein in the eye. The topical steroid eye drops are aimed at reducing swelling in the retina, until the collateral vessels have a chance to develop.

Who can participate

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients must be able to understand the study procedures, agree to participate, and give written consent. * Patient must have central retinal vein occlusion, hemi-retinal vein occlusion or branch retinal vein occlusion. * Patients must be able to follow the study medication regimen. * Patients must agree to return for the once monthly eye exams. * Patients must agree to have liver function tests performed on a regular basis. * Patients must agree to have regular appointments with their Internist on an established basis. Exclusion Criteria: * Patients with active Gout, or high levels of Uric * Patients may not be pregnant or lactating. * The Principal Investigator reserves the right to exclude any patient who he feels will not make a good candidate.

What they're measuring

Number of Participants With An Improvement in Vision, as Measured by an Increase of 15 Letters on the Early Treatment Diabetic Retinopathy Study (EDTRS) Vision Chart.

Timeframe: one year

Trial details

NCT IDNCT00493064

SponsorPalo Alto Medical Foundation

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-10

Results submitted2018-08-27

View on ClinicalTrials.gov More Retinal Vein Occlusion trials