Eflornithine + Nifurtimox Late-Stage Human African Trypanosomiasis (HAT)in West Nile, Uganda

Inclusion Criteria: * Stage 2 infection with Trypanosoma brucei gambiense diagnosed within the previous 14 days, as defined by either of the following: (i) Presence of trypanosomes in blood or lymph node fluid and WBC count in CSF \> 5 / mm3, or (ii) Presence of trypanosomes in the CSF with any CSF WBC count * Residence in the study area * Written informed consent (to be obtained from parent/guardian for children under 18 years and patients with impaired cognition) Exclusion Criteria: * Pregnancy or clinical history suggestive thereof * Weight \< 10 Kg * History of any HAT treatment within the previous 24 months * Inability to undergo hospitalisation or attend follow-up visits during the 24 months following discharge * Severe anemia (Hb\< 5g/dl) * Active tuberculosis (sputum positive) * HIV positive (if patient has been tested and results are known) * Severe renal or hepatic failure * Bacterial or cryptococcal meningitis * Other severe underlying diseases upon admission * Refugee status