Botulinum Toxin Type A for the Treatment of Male Chronic Pelvic Pain Syndrome

Inclusion Criteria: * CPPS NIH III (symptoms over 3 months during the last 6 months, 4 glass-test) * Pain Score ≥ 4 Exclusion Criteria: * During the last month: intake of antibiotics, alpha receptor blockers, anticholinergics; intake of analgesics containing opioids (longer than 4 days); participating in a different clinical trial * During the last 3 months:documented urinary infection, epididymitis, positive urinary culture; status post biopsy of the prostate gland; STD: Gonorrhea, Chlamydia, Mycoplasm, Trichomonads * During the last 6 months: Finasteride or any other 5α-reductase inhibitor * During the last 12 months: status post any surgery on the prostate gland; genital herpes; not adjustable hypertension, angina pectoris, heart failure (NYHA III-IV), Status post myocardial infarction, coronary bypass surgery or coronary dilatation * During the last 24 months: cerebral insult, TIA; active disease of the liver * Other urological diseases like prostate cancer, bladder cancer, status post radiation of the small pelvis, chemotherapy (intravesical or systemic) * Urinary catheter * Residual urine \> 200ml * Serum creatinine \> 200µmol/l * Status post injection of BTX A, hypersensitivity concerning any substances of content of BTX, myasthenia gravis * Any kind of cancer * Active inflammation (except the prostate gland) * Neurological or psychological disease making signing of a consent form or behaving according to a study protocol impossible * Abuse of drugs or alcohol durin…