Quetiapine for Bipolar Disorder and Alcohol Dependence

Inclusion Criteria: * Outpatients with a diagnosis of bipolar I or II disorder, depressed or mixed phase on the Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders (SCID) and confirmed by interview with PI or co-I. * Current diagnosis of alcohol dependence. * Alcohol use (by self-report) of at least 15 drinks in the 7 days prior to baseline. * Currently taking a mood stabilizer defined as lithium, divalproex/valproic acid, oxcarbazepine, or lamotrigine at a stable dose for \> 14 days. * Men and women age 18-65 years old. * English or Spanish speaking. Exclusion Criteria: * Bipolar disorders other than bipolar I or II (e.g., not otherwise specified or cyclothymic disorders) based on the SCID and confirmed through clinical assessment by PI or co-I. * Baseline Young Mania Rating Scale (YMRS) score \> 35 or Hamilton Depression Rating Scale (HRSD) 17 score \> 35. * Current clinically significant psychotic features (hallucinations, delusions, disorganized thought processes). * Evidence of clinically significant alcohol withdrawal symptoms defined as a Clinical Institute Withdrawal Assessment (CIWA-AR) score of \> 8. * History of hepatic cirrhosis or baseline AST or ALT \> 3X upper limit of normal or other clinically significant findings on physical or laboratory examination. * Mental retardation or other severe cognitive impairment. * Prison or jail inmates. * Pregnant or nursing women or women of childbearing age who will not use oral co…