Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain

Inclusion Criteria: * Prior diagnosis of primary brain tumor * No type 2 neurofibromatosis * Underwent fractionated radiotherapy (≥ 23.4 Gy) with or without surgery or chemotherapy for the brain tumor at least 1 year ago * Karnofsky or Lansky performance status 70-100% * Fertile patients willing to use effective contraception * Baseline IQ ≥ 70 on Peabody Picture Vocabulary Test-3 * Stable weight within the past 6 months with no concern of weight loss * Vision aids and hearing aids must be used for all neuropsychologic/neurocognitive tests, If indicated * Able to speak English * More than 6 weeks since prior donepezil hydrochloride, EGb761, methylphenidate hydrochloride, other stimulants, or any other cognitive function-enhancing drug Exclusion Criteria: * Stereotactic radiosurgery as sole treatment * Evidence of disease progression by MRI * Pregnant or nursing * Attention-deficit/hyperactivity disorder before cancer diagnosis * Uncontrolled seizures or uncontrolled endocrinopathies * Uncontrolled comorbidities * Steroid dose greater than physiologic replacement (18-30 mg/m² hydrocortisone or equivalent) * Use of concurrent anticholinergic drugs