Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults

Inclusion Criteria: Part 1 * Healthy adult aged 18 to 40 years. * Women of child-bearing potential should be using hormonal contraception. * Subject had to be available for the study duration, including all planned follow-up visits. Exclusion Criteria: Part 1 * Previous vaccination against yellow fever or Japanese encephalitis * History of flavivirus infection * Any abnormalities of immune system, or using drugs that affect the immune system. * History of anaphylaxis to foods, bee stings, vaccines or drugs. * Receipt of blood or blood products within the preceding 6 months. * Receipt of any vaccine in the preceding 30 days * Seropositive to hepatitis C virus (HCV), hepatitis B surface antigen (HBsAg) or Human immunodeficiency virus (HIV) * Lactation or intended pregnancy in female subjects * Previous or current military service with overseas deployment * Travel to Mexico or other flavivirus endemic areas in the tropics for periods of four weeks or more in the previous ten years. Inclusion Criteria: Part 2 * Aged ≥ 41 years. * Subjects had to be in general good health. * Unimpaired cognitive performance as assessed by clock drawing test score * Subject had to be available for all required study visits, including all planned follow-up visits. * Women of child-bearing potential should be using hormonal contraception. Exclusion Criteria: Part 2 * Clinically significant abnormalities on the Screening 12-lead electrocardiogram (ECG). * An acute or chronic medical condition t…