Sustained Release d-Amphetamine & Buprenorphine on Drug Seeking Behavior in Opioid & Cocaine Dependent Individuals

Inclusion Criteria: * Opioid dependent and Cocaine abuse or dependence, as determined by structured clinical interview for DSM-IV (SCID) and Addiction Severity Index (ASI) * Positive urine test for opiates and cocaine * Willing to use an adequate form of contraception for the duration of the study * Reads and writes English Exclusion Criteria: * Psychiatric illness, as determined by the DSM-IV criteria * History of, or current neurological disease, including structural abnormalities, seizures, infectious disease, history of other neurological diseases or head trauma. * History of cardiovascular disease, myocardial infarction, chest pain or palpations on exertion or drug use * Systolic blood pressure greater than 160 or less than 95 mmHg; Diastolic blood pressure \>95 mmHg * Clinically abnormal ECG * Pulmonary disease, including asthma, obstructive pulmonary disease, cor pulmonale, tuberculosis * Systemic disease (e.g., endocrinopathies, liver or kidney failure, myxedema, hypothyroidism, Addison's disease, autoimmune disease) * Current alcohol or sedative drug dependence * Pregnant or breastfeeding * Currently receiving treatment for a Substance Abuse/Dependence Disorder or seeking treatment * Been in a research study within the last 30 days * Known phobia of injections