Liver Infusions of Fluorouracil in Treating Patients With Dukes' A, Dukes' B, or Dukes' C Colon Cancer Undergoing Surgery

Inclusion Criteria: * more than one synchronous primary colon tumor * white blood cell (WBC) \> 4000/cu.mm. and platelet count greater than or equal to 100,000/cu.mm. * evidence of adequate renal (serum creatinine less than or equal to 1.5 mg%) and hepatic function (bilirubin less than or equal to 1.5 mg%; serum glutamic oxaloacetic transaminase (SGOT) less than or equal to 60 I.U./ml) * performance status of 0, 1 or 2 * Patients with intestinal obstruction are eligible. Preliminary or complementary colostomy does not preclude entry of a patient provided randomization is carried out prior to the planned curative resection. * The distal margin of the tumor must be greater than or equal to 12 cm from the anal verge as endoscopically measured with the patient in the knee-chest position. * Carcinoembryonic antigen (CEA) must be performed pre-operatively but results need not be known at the time of randomization. Exclusion criteria: * malignant colon tumors other than carcinoma, i.e., sarcoma, lymphoma, etc. * patients whose tumors demonstrate free perforation * previous or concomitant malignancy, regardless of site - except patients with squamous or basal cell carcinoma of the skin, and carcinoma in situ of the cervix which have been adequately treated * patients who have received prior treatment other than preliminary or complementary colostomy (radiation, chemotherapy or surgery) for their current malignancy. * patients having tumors within 12 cm of the anal verge * performa…