Secondary Debulking Surgery +/- Hyperthermic Intraperitoneal Chemotherapy in Stage III Ovarian Cancer

Inclusion Criteria: * Age between 18 and 76 years * Histological or cytological proven primary epithelial ovarian carcinoma or peritoneal cancer (PPSC) or fallopian tube carcinoma FIGO stage III, including serous papillary adenocarcinoma, mucinous adenocarcinoma and endometrioid adenocarcinoma. * In case of pleural effusion cytology should be negative for tumour cells * In case diagnosis is made based on cytology only (i.e. patients treated by primary chemotherapy) additional criteria apply: * Normal mammogram (\< 6 weeks before first registration) and * Presence of pelvic mass and * CA 125 \> 200 kU/l and * Serum CA125/CEA ratio \> 25. If the serum CA125/CEA ratio is \< 25, a barium enema or colonoscopy and gastroscopy or radiological examination of the stomach should be negative for the presence of a primary tumour of the digeste tract (\< 6 weeks before registration) and * Omental cake or other metastases larger than 2 cm in the upper abdomen and/or regional lymph node metastasis irrespective of size (CT/MRI or ultrasound or laparoscopy) * Patients eligible for interval debulking for the following 2 reasons: * Primary debulking surgery not feasible due to tumour extension or general condition (patients treated by primary chemotherapy) or * Incomplete primary debulking with residual disease \> 1 cm * In case of primary chemotherapy: * Chemotherapy consists of 3 courses of carboplatin or cisplatin combined with taxol * Following 2 cycles of chemotherapy…