Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria

Inclusion Criteria: * All patients must have confirmatory mutational analysis showing G608G mutation in the lamin A gene. * Patients with progeroid laminopathies, showing clinical signs of Progeria but with other confirmed mutations in LMNA will be eligible for therapy. This population will be analyzed separately from those with the classical mutations. * Patients must be willing and able to come to Boston for appropriate studies and examinations approximately once every 4 months. * Patients must have a minimum of one year of weight data available, with five data points or more, each separated by one month or more over a one year period and approval by the study team. * APC (ANC + bands + monocytes = APC) \> 1,000/ml, Platelets \> 75,000/ml (transfusion independent); Hemoglobin \>9g/dl. * creatinine less than or equal to 1.5 times normal for age or GFR \> 70 ml/min/1.73m2. * bilirubin less than or equal to 1.5 x upper limit of normal for age; SGPT (ALT) \< and SGOT (AST) \< 5 x normal range for age. * PT/PTT \< 120% upper limit of normal OR PI approval. * No overt renal, hepatic, pulmonary disease or immune dysfunction. * Patients taking growth hormone when entering the study must have pretreatment weight measures while on growth hormone which are specified above. In addition, patients must remain on growth hormone treatment for the duration of the present clinical trial. Patients entering the trial not on growth hormone must remain off of growth hormone for the duration of …