A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG

Inclusion Criteria: * Patients must be scheduled to undergo CABG surgery (during routine scheduling times) and had planned to use cardiopulmonary bypass. * Provide informed consent * Age ≥ 18 * Male patients, or female patients not of childbearing potential or who have had a negative pregnancy test and are practicing adequate contraception * Patients must be considered at high risk for subsequent myocardial complications defined as meeting 2 or more of the following: * Age ≥ 65 * Current or recent smoker (within last 6 months) * History of diabetes mellitus requiring treatment other than diet * Evidence of left ventricular dysfunction or congestive heart failure assessed by: * Ejection fraction (EF) ≤ 45% * Left ventricular end diastolic pressure (LVEDP) or pulmonary wedge pressure (PWP) ≥ 20 mm Hg * Pulmonary edema by chest X-ray * Cardiothoracic ratio \> 50% on chest X-ray * History of a previous non-disabling stroke, transient ischemic attack, or carotid endarterectomy * Urgent CABG intervention defined as the need to stay in the hospital (although patient may be operated on within a normal scheduling routine) * History of a myocardial infarction that occurred more than 48 hours but less than 6 weeks prior to CABG surgery * Prior peripheral artery surgery or angioplasty * Moderate renal dysfunction defined as creatinine clearance ≥ 30 ml/min, but \< 60 ml/min * Presence of at least one asymptomatic carotid artery stenosis (≥ 50%) eith…