Randomized Placebo-controlled Study of MDMA-assisted Therapy in People With PTSD - Israel

Inclusion Criteria: * Diagnosis of Posttraumatic stress disorder still remaining after at least one treatment, with treatment including psychotherapy or pharmacotherapy. At least two-thirds of participants will have PTSD as a result of war and terrorism * May meet criteria for a mood disorder. * Must be at least 18 years old. * Must be able to stop taking psychiatric medication from the start of the study until the two-month follow-up. * May continue seeing an outside therapist during the study, but cannot increase the length or frequency of treatments. * Must be able to follow all the rules and instructions relating to the experimental session, including restrictions on food and substance (alcohol and drug) consumption * Must be willing to stay overnight in the clinic after each experimental session until the non-drug session occurring the next morning. * Must be willing to be contacted by one of the researchers on a daily basis for a week after each experimental session. * If a woman of childbearing potential, must have a negative pregnancy test and must agree to use an effective form of birth control. * Must be able to speak and read Hebrew. Exclusion Criteria: * Cannot have history of or be diagnosed with psychotic disorder or bipolar affective disorder - 1. * Cannot be diagnosed with dissociative identity disorder, an eating disorder with active purging, or borderline personality disorder. * Cannot have evidence or history of significant hematological, endocrine, cere…