TerminatedPhase 4

Prolonged Treatment for Infected Abortion After Hospital Discharge.

Stopped: The rate of cure in both arms was higher than expected

Brazil56 participantsStarted 2006-05

Plain-language summary

Patients with infected abortion will be treated with dilatation and curettage, intravenous antibiotics. The purpose of this study is to verify if it is necessary to keep the use of oral antibiotics after hospital discharge.

Who can participate

Age range14 Years – 50 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * History of intrauterine manipulation with contaminated objects. * Vaginal secretion with fetid odor * Presence of pus flowing through the cervical uterine * Presence of peritonitis * Leucocytosis (\> 14,000 leucocytes/mL) * Vasodilatation, bounding pulse and paradoxically warm periphery with tachycardia (Heart rate\> 110 bpm) * Cyanosis and/or paleness * tachypnea(\> 30mpm) * Arterial hypotension (SAP\< 90mmHg) * Oliguria * Fever (\> or = than 37,8°C) Exclusion Criteria: * Refusal to participate in the project * Prior use of antibiotics within one week * Known allergy to Doxycycline or Metronidazole * Presence of tubo-ovarian abscess

What they're measuring

Hospital re-admission

Timeframe: 7 days after hospital discharge

Trial details

NCT IDNCT00376493

SponsorHospital de Clinicas de Porto Alegre

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2007-12

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