Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Modera… (NCT00371332) | Clinical Trial Compass
CompletedPhase 3
Effect of Adjunctive Treatment With Arestin on the Subgingival Microflora in Patients With Moderate to Advanced Periodontitis
United States128 participantsStarted 2004-01
Plain-language summary
The purpose of this study is to measure the antimicrobial effects of Arestin in subjects with moderate to advanced periodontal disease
Who can participate
Age range30 Years – 65 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Generalized moderate to advanced chronic periodontitis, five sites with probing depths of \>5 mm in 5 non-adjacent interproximal spaces, excluding the distal of terminal teeth, at least 16 teeth excluding 3rd molars and implants
Exclusion Criteria:
* Allergy to tetracycline
* Subjects with aggressive periodontitis
* Acute necrotizing ulcerative gingivitis, or gross decay
* Systemic conditions which could influence the course of periodontal disease (i.e, diabetes, autoimmune disease, etc)
* Individuals requiring prophylactic antibiotics
* Any periodontal therapy within the previous 3 months (excluding maintenance therapy)
* Systemic or local antibiotic therapy within three months
What they're measuring
1
The change in the mean sum of primary pathogens (P. gingivalis, To forsythensis, and T. denticola) from baseline to 30 days.