The Effects Of Ropinirole On Mood Or Mild Depression In Patients With Moderate To Severe Restless Legs Syndrome

Inclusion criteria: * diagnosis of idiopathic Restless Legs Syndrome, confirmed by a score of at least 11 on the RLS Diagnostic Index * certain severity of symptoms (at least score of 15 on the International Restless Legs Score (IRLS) * Have had RLS symptoms for at least 15 nights in the last four weeks. * \< 6 hours of sleep in nights with RLS symptoms * MADRS (depression rating scale) score of at least 12 (= borderline to depression) at baseline Exclusion criteria: * any other sleep disorder that might interfere with the RLS symptoms or sleep (e.g. sleep apnea disorder, narcolepsy) * Secondary RLS due to diagnosis of renal insufficiency, polyneuropathy, pregnancy (see below), iron deficiency anemia * Any significant psychiatric disorders (e.g. schizophrenia, bipolar disorder); depression which by judgement of the investigator is caused by RLS, is not an exclusion criterion. * Current or past suicidality * medication known to trigger/aggravate/ cause or interfere with RLS symptoms (e.g. most antidepressants, lithium, neuroleptics, opioids, carbidopa, clonidine, antihistamines, anticonvulsants etc.). * daytime RLS symptoms which require treatment (daytime: 10 a.m. until 6 p.m.). * concomitant movement disorders (e.g. Parkinson's Disease, dyskinesia, dystonia). * medical conditions with symptoms which could affect assessments of efficacy (e.g. diabetes, rheumatoid arthritis, fibromyalgia syndrome, cancer etc.). * Subjects taking any medication known to induce drowsiness or …