A Phase II Open Label Study of BMS-582664 in Locally Advanced or Metastatic Hepatocellular Cancer

Inclusion Criteria: * Diagnosis of hepatocellular carcinoma (HCC) ≥ 2cm based on: * Biopsy OR * Radiological evidence of HCC by contrast-enhanced CT scan or contrast-enhanced AND * Blood test positive for Hepatitis B or C AND * Alpha fetoprotein above \> 400 mg/L * Not appropriate for curative surgery * Screening Blood Pressure \<150/100 mmHg, Left Ventricular Ejection Fraction (LVEF) \>50% Exclusion Criteria: * Heart Attack within 12 months, uncontrolled chest pain within 6 months * Ascites resistant to diuretic medication therapy * Portal-systemic encephalopathy * Portal hypertension with bleeding esophageal or gastric varices within the past 2 months * Deficiency of sodium in the blood with sodium \< 125 mEq/L * Subjects with serious non-healing wounds, ulcers or bone fractures