Comparison of Cephalexin Versus Clindamycin for Suspected CA-MRSA Skin Infections (NCT00352612) | Clinical Trial Compass
CompletedPhase 4
Comparison of Cephalexin Versus Clindamycin for Suspected CA-MRSA Skin Infections
United States200 participantsStarted 2006-09
Plain-language summary
The purpose of this study is to help define the role of antibiotics in the treatment of pediatric skin infections caused by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). The investigators hypothesize that treatment with cephalexin, a penicillin-like antibiotic to which CA-MRSA would be expected to be resistant, does not result in poorer outcomes than treatment with clindamycin, an antibiotic to which CA-MRSA is most often susceptible.
Who can participate
Age range
6 Months – 18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Children between the ages of 6 months and 18 years of age (inclusive)
* Suspected purulent staphylococcal skin or soft tissue infection
* No hospitalization within the previous 14 days
* Must have reliable means of follow-up contact (e.g. working phone)
* Outpatient management in the judgement of treating physician
Exclusion Criteria:
* Hospitalization on initial visit
* Voluntary withdrawal by the treating physician in order to dictate the antibiotic being used
* Patients with a history of hypersensitivity to or intolerance of cephalexin (or other beta lactams) or clindamycin.
* Patients with altered immunity (inherited or acquired)
* Patients with skin infections related to surgical wounds or hardware.
* Patients currently on antibiotic therapy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Clinical Improvement at the 48-72 Hour Clinical Follow-up