Dietary Supplements for the Treatment of Angelman Syndrome

Inclusion Criteria: * Diagnosis of AS * In stable condition with relatively good control of seizures * Willing to comply with treatment, study visit schedule, and study assessments * Willing to take oral or G-tube medication * Willing to be contacted monthly during the course of the study * Parent or guardian willing to provide informed consent Exclusion Criteria: * History of liver or kidney disease * Currently being treated for a serious acute illness * Known hypersensitivity to any of the study drugs * Received high-dose folate drug treatment in the 12 months prior to study entry * Other significant medical problems, including those involving the liver, kidney, or heart * Other comorbidities, genetic disorders, or extreme prematurity; children with autism are not excluded