CompletedPhase 3

Efficacy of Lansoprazole in Chronic Post Nasal Drip

United States75 participantsStarted 2006-08

Plain-language summary

The purpose of this study is to determine whether aggressive acid suppression with Lansoprazole is effective in the treatment of post nasal drip, and also assess the predictors of response based on clinical and physiologic parameters.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Negative RAST inhalant allergy panel OR negative skin testing (Group A) * Positive RAST or Positive skin testing AND insufficient response to all of the following: (Group B) * Allergen avoidance * Topical nasal steroids * Allergy shots if indicated * Antihistamines * Negative CT sinuses (coronal) * \< 4mm of mucosal thickening and \< 3 sinus sites * Absence of air-fluid levels * Negative anterior rhinoscopy * Absence of pus, crusts on mucosal surfaces Exclusion Criteria: * Age \< 18 * Pregnancy, confirmed by urine pregnancy test at day of randomization * Ciliary dyskinesia * Immune deficiency * Cystic fibrosis * Diagnosis of acute sinusitis or chronic RS (AAO-HNS) * Active use of topical decongestant * Use of PPI within the last 30 days * Previous fundoplication * Uncontrolled thyroid disease * Isolated chronic cough without the symptom of post nasal drip

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Post Nasal Drainage Symptom Response

Timeframe: 8 and 16 weeks

Trial details

NCT IDNCT00335283

SponsorVanderbilt University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2008-12

Results submitted2011-03-28

View on ClinicalTrials.gov More Larynx Disease trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.