Efficacy of Lansoprazole in Chronic Post Nasal Drip (NCT00335283) | Clinical Trial Compass
CompletedPhase 3
Efficacy of Lansoprazole in Chronic Post Nasal Drip
United States75 participantsStarted 2006-08
Plain-language summary
The purpose of this study is to determine whether aggressive acid suppression with Lansoprazole is effective in the treatment of post nasal drip, and also assess the predictors of response based on clinical and physiologic parameters.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Negative RAST inhalant allergy panel OR negative skin testing (Group A)
* Positive RAST or Positive skin testing AND insufficient response to all of the following: (Group B)
* Allergen avoidance
* Topical nasal steroids
* Allergy shots if indicated
* Antihistamines
* Negative CT sinuses (coronal)
* \< 4mm of mucosal thickening and \< 3 sinus sites
* Absence of air-fluid levels
* Negative anterior rhinoscopy
* Absence of pus, crusts on mucosal surfaces
Exclusion Criteria:
* Age \< 18
* Pregnancy, confirmed by urine pregnancy test at day of randomization
* Ciliary dyskinesia
* Immune deficiency
* Cystic fibrosis
* Diagnosis of acute sinusitis or chronic RS (AAO-HNS)
* Active use of topical decongestant
* Use of PPI within the last 30 days
* Previous fundoplication
* Uncontrolled thyroid disease
* Isolated chronic cough without the symptom of post nasal drip