Pyronaridine and Artesunate (3:1) in Children With Acute Uncomplicated Plasmodium Falciparum Malaria

Inclusion Criteria: Patients presenting with symptoms of acute uncomplicated falciparum malaria with the following inclusion criteria: * Male or female children, being between 2 and 14 years of age inclusive * Weight between 10 and 40 kg inclusive * Written informed consent, in accordance to local practice, provided by parent/guardian. If the parent/guardian is unable to write, witnessed consent is permitted according to local ethical considerations. Where possible, parent assent will be sought * Absence of severe malnutrition (defined as mid upper arm circumference \<110mm) * Presence of acute symptomatic uncomplicated P. falciparum malaria with a diagnosis confirmed by a positive blood smear with asexual forms of P. falciparum only (i.e. no mixed infection) plus measured temperature of ≥37.5°C (depending on method of measurement as below) or history of fever within the past 24 hours : * the acceptable range is between 1,000 and 200,000 asexual parasite count/μl of blood and * axillary/tympanic temperature of ≥37.5°C or oral/rectal temperature of ≥38.0°C * Females of childbearing potential are not allowed to be pregnant or lactating and must be willing to use adequate measures of contraception during the study period * Ability to comply with the study visit schedule and the study protocol for the duration of the study Exclusion Criteria: * Patients with signs and symptoms of severe/complicated malaria requiring parenteral antimalarial treatment according to the WHO Crite…