Effect of Aprotinin on Transfusion Requirements in Patients Undergoing Elective Spinal Fusion Surgery

Inclusion Criteria: * Subjects requiring elective spinal fusion surgery involving 3 to 7 vertebral levels with instrumentation. One vertebral level is defined as encompassing two vertebral bodies and one inter-vertebral disc space, so that a contiguous spinal fusion involving 3 vertebral levels would include 4 vertebral bodies and 3 inter-vertebral disc spaces. Exclusion Criteria: * Subjects with previous exposure to aprotinin in the last 6 months. If the subject has undergone cardiac surgery in the last 6 months, all attempts should be made to ascertain if aprotinin was administered during cardiac surgery. If no records are available, or if the subject received aprotinin, the subject should be excluded.- Subjects with a known or suspected allergy to aprotinin. * Subjects with sepsis or a known bone infection.- Subjects with known bone malignancy. * Subjects with a creatinine clearance less than 30mL/min as calculated by the Cockcroft-Gault formula. * Subjects with a history of bleeding diathesis or known coagulation factor deficiency. * Subjects with failure of a major organ system or any active significant medical illness that in the opinion of the Investigator is likely to affect the subject's ability to complete the study or precludes the subject's participation in the study * Subjects who refuse to receive allogenic blood products for religious or other reasons. * Subjects whose preoperative red blood cell volume is so low that a blood transfusion would be likely to b…