AZD2171 in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibroma and/or Neurofibroma Near the Spine

Inclusion Criteria: * Diagnosis\* of neurofibromatosis type 1 (NF1) and extensive plexiform and/or paraspinal neurofibromasproducing pain (not controlled by use of over-the-counter medications), progressive neurologic deficit, or significant neurologic consequenceswith continuous tumor growth * Extensive paraspinal neurofibroma defined as a neurofibroma that involves multiple neural roots at ≥ 3 spinal levels with connection between the levels or extending laterally along the nerves * Symptomatic neurofibromas at \< 3 spinal levels, but surgical treatment is not possible, allowed * Meets ≥ 2 diagnostic criteria for NF1, including the following: * Six or more café-au-lait spots (≥ 1.5 cm in postpubertal patients) * Freckling in the axilla or groin * Optic glioma * Two or more Lisch nodules * Distinctive bony lesion (dysplasia of the sphenoid bone or dysplasia orthinning of long-bone cortex) * First-degree relative with NF1 * Patients with documented mutation in neurofibromin gene with onlysymptomatic plexiform and/or paraspinal neurofibroma who do not fulfill the above clinical criteria are eligible * Measurable disease, defined as ≥ 1 lesion whose longest diameter can beaccurately measured as 8.0 cm\^3 with 3-dimensional (3D) MRI * Skin lesions are consideredmeasurable (e.g., plexiform neurofibromas), but MRI imaging still required for 3D measurement * Patients with symptomatic neurofibroma, in whom surgery is not feasible, who refuse surgery or are n…