Simultaneous Pancreas-kidney Transplantation With Campath Protocol

Inclusion Criteria: * Male or female patients of 18 to 55 years of age with end-stage, C-peptide-negative, Type 1-diabetic nephropathy. * Female patients of childbearing age must have a negative pregnancy test and must agree to maintain effective birth control practice throughout the study period (3 years). * Patient must have signed the Patient Informed Consent Form. * Patient must receive a primary simultaneous pancreas-kidney (SPK) cadaveric transplant, with either intestinal or bladder and either portal or systemic venous drainages. Exclusion Criteria: * Patient is pregnant or breastfeeding. * Patient is allergic or intolerant to Mycophenolate Mofetil, Tacrolimus or other macrolides, or any compounds structurally related to these compounds. * Past history of anaphylaxis following exposure to humanized monoclonal antibodies. * Patient has a positive T-cell crossmatch on the most recent serum specimen. * CMV-match: D+ / R-. * Patient is known for active liver disease or has significant liver disease; defined by ASAT and ALAT serum levels greater than 3 times the upper limit of normal. * Patient has malignancy or history of malignancy, with the exception of adequately treated localised squamous cell or basal cell carcinoma, without recurrence. * Patient has been included in another clinical trial protocol for any investigational drug within 4 weeks prior to randomisation. * Patient has any form of substance abuse, psychiatric disorder or condition, which, in the opinion o…