Combination Chemotherapy Followed by Rituximab and Yttrium Y 90 Ibritumomab Tiuxetan in Treating … (NCT00310128) | Clinical Trial Compass
WithdrawnPhase 2
Combination Chemotherapy Followed by Rituximab and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Relapsed or Refractory AIDS-Related Non-Hodgkin's Lymphoma
Stopped: Drug supply unavailable
0Started 2006-02
Plain-language summary
RATIONALE: Drugs used in chemotherapy, such as etoposide, methylprednisolone, cytarabine, and cisplatin, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab and yttrium Y 90 ibritumomab tiuxetan, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them without harming normal cells. Giving more than one drug (combination chemotherapy) together with rituximab and yttrium Y 90 ibritumomab tiuxetan may kill more cancer cells.
PURPOSE: This phase II trial is studying how well giving combination chemotherapy together with rituximab and yttrium Y 90 ibritumomab tiuxetan works in treating patients with relapsed or refractory AIDS-related non-Hodgkin's lymphoma.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically or cytologically documented B-cell non-Hodgkin's lymphoma, including any of the following histologic types:
* Follicular large B-cell lymphoma (follicular, grade 3)
* Follicular mixed cell lymphoma (follicular, grade 2)
* Diffuse mixed cell lymphoma
* Diffuse large B-cell lymphoma
* Immunoblastic lymphoma
* Burkitt or Burkitt-like lymphoma
* Anaplastic large cell lymphoma
* Primary effusion lymphoma
* All stages eligible
* Seropositive for HIV by any approved test or positive HIV-1 RNA in plasma at anytime in the past
* Prior documentation of HIV seropositivity allowed
* Received 1 prior anthracycline-based regimen of curative intent
* No more than 1 prior regimen
* Measurable or evaluable disease
* Evaluable disease defined as not having bidimensional measurements (i.e., gastric or marrow involvement) but can be followed for response by other diagnostic tests, such as gallium scan, positron emission tomography (PET) imaging and/or bone marrow biopsy
* No primary CNS lymphoma
* Lymphomatous meningitis or brain metastasis eligible provided other measurable systemic lymphomatous disease is also present
* Less than 25% bone marrow involvement with lymphoma
* Concurrent effective highly active anti-retroviral therapy (HAART) required at study entry
* HIV viral load \< 100,000 copies/mL if HAART was not used previously
PATIENT CHARACTERISTICS:
* Karnofsky performance status 50-100%
* Bilirubin ≤ 2.0 mg/dL (unless elevated due to lymphom…