Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke

Inclusion Criteria: * Meets DSM-IV criteria for schizophrenia or schizoaffective disorder * Receiving a stable dose of antipsychotic medication for at least 1 month prior to study entry * Smokes at least 10 cigarettes per day * Wishes to stop smoking * Attended last three scheduled clinic visits, prior to study entry Exclusion Criteria: * Significant medical or neurologic illness * History of severe head injury with loss of consciousness * Treated with monoamine oxidase inhibitors or carbamazepine in the 14 days prior to study entry * Taking clozapine at doses greater than 500 mg/d without an anticonvulsant * Currently undergoing an acute exacerbation of psychotic symptoms * Current or history of bulimia or anorexia * Current excessive water intake * Recent history of mania * Known allergy or hypersensitivity to bupropion * Current substance abuse other than tobacco, nicotine replacement treatment, or smokeless tobacco * Currently receiving treatment with bupropion * Pregnant or breastfeeding