Evolution of Pain From Herpes Zoster (NCT00305357) | Clinical Trial Compass
CompletedNot Applicable
Evolution of Pain From Herpes Zoster
United States100 participantsStarted 2001-11
Plain-language summary
Evolution of pain and neural injury will be evaluated at 2 years or longer after the onset of AHZ by multiple measures. Assessments at 2 years or longer will be compared to those collected during the first 6 months after HZ in order to test whether or not sensory function and cutaneous innervation continues to normalize beyond 6 months in subjects who recover from HZ without severe PHN.
Who can participate
Age range50 Years
SexALL
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Inclusion criteria
✓. Males and females aged 50 or older and in stable general health.
✓. Able and willing to provide written informed consent.
✓. Able to understand and follow the instructions of the investigator, including the pain intensity rating scales.
✓. Subjects must have an acute outbreak of cervical, thoracic or lumbosacral HZ with unilateral skin rash and pain; the diagnosis will be based on physical examination and review of available medical records confirming the outbreak.
✓. The outbreak of herpes zoster must have occurred less than 6 weeks prior to study entry.
✓. PHN pain must be of at least moderate severity, defined as self-report of average pain level of 20 mm on a 100 mm visual analog scale.
Exclusion criteria
✕. The AHZ outbreak is complicated by stroke or myelopathy.
✕. Patients with facial or cranial AHZ.
✕. Patients with signs of spinal cord or brainstem injury from HZ.
✕. Patients who are considered unreliable as to study compliance or adherence to scheduled appointments as determined by the Investigators.
✕. Patients, who are undergoing active treatment for cancer, are infected with the Human Immunodeficiency Virus, or are being acutely and intensively immunosuppressed following a transplantation procedure.