Compassionate Use of Nitazoxanide for the Treatment of Clostridium Difficile Infection

Inclusion Criteria: * Patient must be \> 18 years of age * Clinical diagnosis of C. difficile associated disease, based on the new onset of diarrhea, abdominal discomfort, or otherwise unexplained fever or leukocytosis * Diagnosis of C. difficile colitis proven by positive assay for C. difficile toxin in feces * Disease has been treated, and the symptoms failed to respond to treatment with metronidazole or vancomycin, or symptoms promptly relapsed after completing a course of therapy with either of these drugs * Able to take oral medication Exclusion Criteria: * Patients with other recognized causes of diarrhea or colitis * Women of child bearing age who are pregnant, breast feeding, or not using birth control * Patients taking coumadin, phenytoin, celecoxib, or losartan * Patients with renal insufficiency (BUN or creatinine \>2 times baseline) * Serious systemic disorder incompatible with the study