Cryotherapy in Treating Patients With Primary Lung Cancer or Lung Metastases That Cannot Be Remov… (NCT00303901) | Clinical Trial Compass
CompletedNot Applicable
Cryotherapy in Treating Patients With Primary Lung Cancer or Lung Metastases That Cannot Be Removed By Surgery
United States40 participantsStarted 2005-11
Plain-language summary
RATIONALE: Cryotherapy kills tumor cells by freezing them. This may be an effective treatment for primary lung cancer or lung metastases that cannot be removed by surgery.
PURPOSE: This clinical trial is studying how well cryotherapy works in treating patients with primary lung cancer or lung metastases that cannot be removed by surgery.
Who can participate
Age range18 Years – 120 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
DISEASE CHARACTERISTICS:
* Histologically or cytologically confirmed malignant pulmonary neoplasm
* New lung lesion(s) with definitive clinical and imaging features of primary or metastatic disease allowed
* Imaging findings compatible with localized treatment failure after prior cryotherapy allowed
* Malignant pleural effusion allowed provided it is associated with a distinct measurable pulmonary mass amenable to cryotherapy
* Metastatic disease must meet all of the following criteria:
* Primary tumors have been resected or have been deemed controlled by other therapies
* No other widespread metastases evident (e.g., multiple hepatic or brain metastases)
* Each pulmonary mass must be amenable to CT-guided percutaneous cryotherapy approach
* No more than 5 targeted masses for study therapy
* Target mass defined as pulmonary, hilar, mediastinal, and/or chest wall mass \> 1 cm, but \< 10 cm in average diameter
* Unresectable disease by surgical consultation OR patient refused surgical options
* Nonenhanced and enhanced CT scan required within the past 6 weeks done at 4-5 mm increments with available soft tissue and mediastinal windows to assess size and extent of all thoracic tumors
* PET scan required within the past 6 months noting the correlation with the above CT locations, if not already obtained by a combined PET/CT scanner
PATIENT CHARACTERISTICS:
* Karnofsky performance status (PS) \> 60-100% OR WHO/ECOG/Zubrod PS 0-2
* FEV\_1 \> 30% of predicted
* DLCO…