Study of the Safety of Intravenous Artesunate

Inclusion Criteria: * Healthy adult males and non-pregnant, non-lactating females * Have a normal ECG that may include benign PAC's and PVC's, 1st degree AV block, 2nd degree AV block, Wenckebach * Have a normal blood pressure (BP) and heart rate (HR). These will be measured after resting supine for about 3 minutes. Normal BP is defined as less than 140 mm Hg systolic and less than 90 mm Hg diastolic. Normal baseline HR is 50 to 90 bpm without symptoms. * Body mass index between 18 and 29 kg/m\*\*2 or, if out of range, not clinically significant (within 15% of their ideal body weight). * Be able to verbalize understanding of the consent form, provide written informed consent and verbalize willingness to complete study procedures * Have a brief physical examination that demonstrates no clinically significant contraindication for participating in the study. * If female, have a negative serum pregnancy test at screening and urine pregnancy at admission or be postmenopausal, had a hysterectomy, been sterilized, or agrees to practice effective contraception for the duration fo the study and for a period of 12 weeks after stopping study drug. Exclusion Criteria: * Have received any investigational drug or vaccine in the period 0 to 16 weeks before entry to the study. * Have been on a liquid protein diet in the last year * Have any clinically significant abnormal physical findings at the screening examination * Have any clinically significant abnormalities in the results of labor…