This study evaluates the immunogenicity and consistency of 3 Hib-MenCY-TT vaccine lots and the safety and immunogenicity of Hib-MenCY-TT vaccine compared to a control group receiving licensed Hib conjugate vaccine, when each are co-administered with Pediarix® to healthy infants at 2, 4, and 6 months of age. The study will also evaluate the safety and immunogenicity of Hib-MenCY-TT vaccine compared to a control group receiving licensed Hib conjugate vaccine, when each are co-administered with M-M-R® II and Varivax® at 12 to 15 months of age.
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Anti-Polyribosyl Ribitol Phosphate (PRP) Antibody Concentrations
Timeframe: One month after primary vaccination
Neisseria Meningitidis Serogroup C (MenC) Serum Bactericidal Assay Using Human Complement (hSBA) Antibody Titers
Timeframe: One month after primary vaccination
Neisseria Meningitidis Serogroup Y (MenY) Serum Bactericidal Assay Using Human Complement (hSBA) Antibody Titers
Timeframe: One month after primary vaccination
hSBA-MenC Antibody Titers
Timeframe: Prior to the fourth dose vaccination and 42 days after the fourth dose
hSBA-MenY Antibody Titers
Timeframe: Prior to the fourth dose vaccination and 42 days after the fourth dose
Number of Subjects With Anti-PRP Antibody Concentration Equal to or Above 1.0 Microgram Per Milliliter (µg/mL)
Timeframe: One month after primary vaccination
Number of Subjects With hSBA-MenC Titer Equal to or Above 1:8
Timeframe: 42 days after the fourth dose
Number of Subjects With hSBA-MenY Titer Equal to or Above 1:8
Timeframe: 42 days after the fourth dose
Number of Subjects With Anti-measles Antibody Concentrations Equal to or Above 150 Milli-international Units Per Milli-liter (mIU/ML)
Timeframe: 42 days after the fourth dose
Number of Subjects With Anti-PRP Antibody Concentration Equal to or Above 1.0 Microgram Per Milliliter
Timeframe: 42 days after the fourth dose
Number of Subjects With Anti-mumps Titer Equal to or Above 28 Estimated Dose 50 (ED50)
Timeframe: 42 days after the fourth dose
Number of Subjects With Anti-rubella Antibody Concentrations Equal to or Above 10 International Units Per Milli-litre (IU/mL)
Timeframe: 42 days after the fourth dose
Number of Subjects With Anti-varicella Titer Equal to or Above 1:5
Timeframe: 42 days after the fourth dose