The SOS (Stenting Of Saphenous Vein Grafts) Trial

Inclusion Criteria: * at least one 50-99% de-novo or restenotic lesion in a saphenous vein graft that is between 2.5 and 4.0 mm in diameter, requiring percutaneous coronary intervention according to the opinion of the attending cardiologist * willing to return for repeat coronary angiography after 12 months * able to give informed consent Exclusion Criteria: * previous or planned use of intravascular brachytherapy in the target vessel * a left ventricular ejection fraction of less than 25 percent * hemorrhagic diatheses * contraindications or allergy to aspirin, thienopyridines, paclitaxel, or stainless steel * a history of anaphylaxis in response to iodinated contrast medium * use of paclitaxel within 12 months before study entry or current use of colchicine * a serum creatinine level of more than 2.0 mg per deciliter (177 µmol per liter) * a leukocyte count of less than 3500 per cubic millimeter, or a platelet count of less than 100,000 per cubic millimeter * a recent positive pregnancy test, breast-feeding, or the possibility of a future pregnancy * coexisting conditions that limit life expectancy to less than 24 months or that could affect a patient's compliance with the protocol