Circadian Rhythms and Sleep in Familial DSPS and ASPS (NCT00246454) | Clinical Trial Compass
CompletedNot Applicable
Circadian Rhythms and Sleep in Familial DSPS and ASPS
United States156 participantsStarted 2003-09
Plain-language summary
The purpose of this study is to determine the properties of circadian rhythms and sleep propensity in familial advanced and delayed sleep phase syndrome (DSPS).
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria for ASPS Participants:
* Morning type score on the Horne-Ostberg questionnaire
* Advanced melatonin onset
Inclusion Criteria for DSPS Participants:
* Evening type score on the Horne-Ostberg questionnaire
* Delayed melatonin onset
Inclusion Criteria for Controls:
* A stable sleep/wake pattern with a normal phase relationship to the environment and no history of sleep disorders
Exclusion Criteria for all subjects:
* Sleep disorder, other than DSPS or ASPS, as assessed by the Pittsburgh Sleep Quality Index and/or by polysomnogram
* History of cognitive or other neurological disorders
* History of Diagnostic and Statistical Manual-IV criteria for any major psychiatric disorder, alcohol or substance abuse
* Abnormal mood as assessed by the Hamilton Depression Scale
* History of, or concurrent, unstable or serious medical illness
* Current use of psychoactive medications, including antidepressants, anxiolytics, neuroleptics, anticonvulsants, hypnotics, and stimulant medications
* Shift work
* Having a daily caffeine intake greater than 4 cups per day
* Smoking
* Travel across more than 2 time zones within 90 days of the study
* Pregnancy or the desire to become pregnant during the study period