Prospective Pilot Study on Metabolism and Weight Changes in Topiramate-Treated Epilepsy Patients

Inclusion Criteria: * A diagnosis of partial onset epilepsy, with or without secondary generalization. Patients with a diagnosis of epilepsy characterized by primary generalized tonic-clonic seizures may also qualify * Currently taking one or more anti-epileptic medications on a stable dose for one month * Weight between 40 and 130 kg (88 to 286 lbs) * Female patients must be postmenopausal for at least 1 year, surgically incapable of childbearing, practicing an acceptable method of contraception (requires negative pregnancy test). Exclusion Criteria: * Patients with rapidly progressive disorders that may impair their weight or their reliable participation in the study * Patients prone to severe malabsorption and/or metabolic disorders * Patients who have mental retardation or impairment which would confound the interpretation of this study * History (within the past six months) of a psychiatric or mood disorder requiring medical treatment * History of poor compliance with past anti-epileptic drug therapy * Suicide attempt in the past five years