Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB (NCT00236249) | Clinical Trial Compass
CompletedPhase 3
Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB
France110 participantsStarted 2005-05
Plain-language summary
The purpose of this study is to check if lidocaine intravenous administration during surgery and 24 hours after surgery, associated with standardised management of the patient, helps to accelerate recovery and to improve the quality of recovery, after surgery for colic or rectal neoplasms.
Who can participate
Age range18 Years – 75 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Colorectal neoplasm
* Radical surgery
* Median incision
Exclusion Criteria:
* American Society of Anesthesiologists (ASA) score equal to or up to 3
* Unwilling or unable to use patient-controlled analgesia (PCA)
* Chronic consumption of opioids
* Chronic drug or alcohol abuse
* Chronic pain
* Unable to read or write text
* Inflammatory disease of intestinal tract
* Allergy to morphine
* Allergy to lidocaine
* Severe atrioventricular conduction dysfunction without stimulator
* Porphyry
* Uncontrolled epilepsy
* History of malign hyperthermia
* Severe cardiac failure
* Hepatic failure
* Myasthenia
* Treatment with beta blockers, antiarrhythmic calcium blockers, sultopride, nonselective monoamine oxidase inhibitor (MAOI)
* Locoregional anaesthesia planned
* Associated surgery concerning liver, pancreas, or gall bladder
* Laparoscopic surgery
* Severe psychiatric pathology
* Refusal of the patient