Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB (NCT00236249) | Clinical Trial Compass
CompletedPhase 3
Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB
France110 participantsStarted 2005-05
Plain-language summary
The purpose of this study is to check if lidocaine intravenous administration during surgery and 24 hours after surgery, associated with standardised management of the patient, helps to accelerate recovery and to improve the quality of recovery, after surgery for colic or rectal neoplasms.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Colorectal neoplasm
* Radical surgery
* Median incision
Exclusion Criteria:
* American Society of Anesthesiologists (ASA) score equal to or up to 3
* Unwilling or unable to use patient-controlled analgesia (PCA)
* Chronic consumption of opioids
* Chronic drug or alcohol abuse
* Chronic pain
* Unable to read or write text
* Inflammatory disease of intestinal tract
* Allergy to morphine
* Allergy to lidocaine
* Severe atrioventricular conduction dysfunction without stimulator
* Porphyry
* Uncontrolled epilepsy
* History of malign hyperthermia
* Severe cardiac failure
* Hepatic failure
* Myasthenia
* Treatment with beta blockers, antiarrhythmic calcium blockers, sultopride, nonselective monoamine oxidase inhibitor (MAOI)
* Locoregional anaesthesia planned
* Associated surgery concerning liver, pancreas, or gall bladder
* Laparoscopic surgery
* Severe psychiatric pathology
* Refusal of the patient
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.