Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients

Inclusion Criteria: * Age 3-18 years * Moderate state of renal failure (creatinine clearance 15 - 75 ml / min / 1.73 m²) * Mean arterial blood pressure (ABPM) \> 50.percentile and/or antihypertensive treatment * Written informed consent Exclusion Criteria: * Age \<3 years or \>18 years at start of study * Unstable clinical condition (vomiting, anorexia, etc) or superimposed important disease * Unilateral or bilateral renal artery stenosis * Urological surgery possibly affecting renal function expected during study period * Insufficient compliance with prescribed antihypertensive medication during the run-in period * Secondary renal diseases such as lupus, amyloidosis and primary hyperoxaluria, and patients treated with immunosuppressive agents (including corticosteroids) * Severe primary cardiac disease, hepatic insufficiency and malabsorption syndrome * Erythropoietin or growth hormone therapy with a duration of less than 3 months prior to run-in period * Pregnancy